Neural Prolotherapy FAQ

What is Neural Prolotherapy?

Neural Prolotherapy also called Neurofascial Prolotherapy (NFP) is a treatment for inflammation and pain of subcutaneous nerves and surrounding tissues. NFP involves a series of small injections of low dose (5%) dextrose (sugar water) just beneath the skin surface close to the subcutaneous nerves.

How does it work?

When we injure tissue, pro-inflammatory substances are released that activate a channel on the nerve called the Transient Receptor Potential V1 (TrpV1). When this channel is activated the nerve releases substances that cause inflammation leading to swelling, hypersensitivity, and pain. NFP works by allowing dextrose to bind to and inhibit the TrpV1 nerve receptor, preventing this inflammatory cascade and restoring normal nerve function.

What does it help?

In traditional prolotherapy, dextrose is used to promote healing in connective tissues including ligaments and tendons. Nerves also have connective tissue and by injecting a low dose of dextrose under the skin we can begin to decrease swelling, reduce pain and improve function. Since the nerves that supply these tissues also supply the deeper structures below, muscles and joints, restoration also affects these deeper structures.

NFP can help to treat nerve pain associated with joints, muscles, tendons, and ligaments. It has also been shown to be effective in treatment for post-surgical pain following back or joint replacement surgeries.

What can I expect during the treatment?

NFP is generally well tolerated. Multiple injections are performed in a grid like pattern over the affected area along the subcutaneous nerves using small needles. Some patients may experience mild discomfort since local anesthetics are not used. Most patients notice an immediate reduction of pain that can last hours to days. Pain is generally reduced by 10-20% with each treatment session. Every patient responds differently but generally, 5-8 treatments may be needed 1-2 weeks apart depending on the degree of injury. NFP is often combined with trigger point injections for maximum benefit.

What are the potential risks and complications

NFP is a safe and effective treatment with minimal risk for infection. Potential risks may include pain at the injection site, allergic reaction, infection at the injection site and injury to tissues at the injection site.

Neuro Therapy Consent Form